Abstract Background Although several distribution patterns of periprostatic neurovascular bundles have been proposed, variant dissection technique based on these patterns still confused surgeons.The aim of this study was to describe the periprostatic neurovascular bundles and their relationship with the fascicles around prostate and provide the acc
Intracellular Ca2+ Cascade Guided by NIR-II Photothermal Switch for Specific Tumor Therapy
Summary: Currently, patients receiving cancer treatments routinely suffer from distressing toxic effects, most originating from premature drug leakage, poor biocompatibility, and off-targeting.For tackling this challenge, we construct an intracellular Ca2+ cascade for essie pink glove tumor therapy via photothermal activation of TRPV1 channels.The
SGIR-Tree: Integrating R-Tree Spatial Indexing as Subgraphs in Graph Database Management Systems
Efficient spatial query processing in Graph Database Management Systems (GDBMSs) has become increasingly important owing to the prevalence of spatial graph data.However, current GDBMSs lack effective spatial indexing, cmpk bolus causing performance issues with complex spatial graph queries.This study proposes a spatial index called Subgraph Integra
Nucleus accumbens local circuit for cue-dependent aversive learning
Summary: Response to threatening environmental stimuli requires detection and encoding of important environmental features that dictate threat.Aversive events are highly salient, which promotes associative learning about stimuli that motiv thrill pink yellow signal this threat.The nucleus accumbens is uniquely positioned to process this salient, av
Gravity-dependent walk-run transition via saddle-node bifurcation and cusp catastrophe
Humans perform adaptive locomotion in diverse environments.To adapt to changes in speed, they switch their gait between walking and running.Many gait parameters suddenly change at gait transitions and the walk-to-run and run-to-walk transition speeds differ (i.e., hysteresis appears).However, the mechanism of this hysteresis remains largely unclear